rifabutin will lower the extent or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
The most typical Uncomfortable side effects of modafinil are listed beneath. Tell your healthcare company if you have any of those Unintended effects that bother you.
Observe Intently (two)modafinil will minimize the level or impact of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Sturdy or average CYP3A4 inducers may well improve fee of diazepam elimination; hence, efficacy of diazepam may very well be lowered.
mitotane decreases amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Mitotane is a strong inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for achievable dosage adjustments.
acetazolamide will increase the stage or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
Even though the results of modafinil are just like These of amphetamines like Adderall, it’s a very distinctive substance. Modafinil is a eugeroic that particularly increases alertness, even though Adderall along with other amphetamines are psychostimulants that develop a temporary boost in Over-all psychomotor action.
fosphenytoin will minimize the extent or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
No certain dose adjustment advisable when tofacitinib coadministered with strong CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both of those moderate CYP3A4 and potent CYP2C19 inhibitors .
Birth Manage drugs along with other hormone-based mostly start Manage may not get the job done in addition to forestall pregnancy. Use Various other form of start Management also, just like a condom, when having modafinil and for one month following the past dose.
tecovirimat will raise the amount or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Check for adverse outcomes if coadministered with sensitive substrates of those enzymes.
apalutamide will website minimize the extent or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine that happen to be CYP3A4 substrates may end up in lower exposure to those drugs.
crofelemer raises amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Crofelemer has the opportunity to inhibit CYP3A4 at concentrations anticipated inside the intestine; not likely to inhibit systemically because minimally absorbed.
Keep track of Closely (one)enasidenib will enhance the level or result of modafinil by influencing hepatic enzyme CYP2C19 metabolism.
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